Come Pick Me Up - Ryan Adams (2000)
A cheating, stealing low-down girlfriend is told what's what (the lines about using the bed for sleeping instead... so good!!) in this, the finest song ever written by the greatest songwriter of '00-'01. While many of Adam's tunes have been exceptional since, he has never captured a painful moment with such expertise as this again.
Watch him blow Letterman's mind (sans the "F" and "S" words) below